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Sayeed Ul hasan, S. M.
- Evaluation of Gastroprotective Influence of Vitamin C, Melatonin, Rabeprazole and their Combination in Ethanol Induced Ulcer Model
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Methodology: The study was divided into 2 dosage groups-single and multiple dose study groups. Each of the dosage group consists of wistar albino rats of either sex (180-220g) divided into 4 groups of 6 animals each.
In single dose study, The animals were fasted for 48h. At the end of 48h, the animals were administered with the drugs. 1h after drug administration, absolute ethanol (1ml/200g p.o.) was administered to all groups. 2h after ethanol administration, the animals were euthantised and stomachs were excised out. In multiple dose study, the animals were administered with drugs for 7 consecutive days. On 7th day following drug administration, the animals were fasted for 48h. At the end of 48h, the aimals were administered with absolute ethanol (1ml/200g p.o.) 2h after ethanol administration, the animals were euthantised, stomachs were excised out. The stomachs excised out from both the study groups were evaluated for ulcer index and percentage protection. However, for multiple dose study group histopathological study was also performed to evaluate cytoprotection.
Result: The results were interpreted statistically using one way ANOVA. The combination group (rabeprazole + vitamin C and rabeprazole + Melatonin) showed significant antiulcer activity in both single and multiple dose study groups, on comparison with rabeprazole, vitamin C and melatonin individually.
Conclusion: The effect of combination groups was found to be synergistic in nature and more effective in treating peptic ulcer disease.
Authors
Affiliations
1 HKES College of Pharmacy, Sedam Road, Gulbarga–585 105 Karnataka, IN
1 HKES College of Pharmacy, Sedam Road, Gulbarga–585 105 Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 3 (2013), Pagination: 155-161Abstract
Aim: To evaluate the gastroprotective effect of the antioxidants (vitamin C and melatonin), rabeprazole and their combination in ethanol induced peptic ulcers.Methodology: The study was divided into 2 dosage groups-single and multiple dose study groups. Each of the dosage group consists of wistar albino rats of either sex (180-220g) divided into 4 groups of 6 animals each.
In single dose study, The animals were fasted for 48h. At the end of 48h, the animals were administered with the drugs. 1h after drug administration, absolute ethanol (1ml/200g p.o.) was administered to all groups. 2h after ethanol administration, the animals were euthantised and stomachs were excised out. In multiple dose study, the animals were administered with drugs for 7 consecutive days. On 7th day following drug administration, the animals were fasted for 48h. At the end of 48h, the aimals were administered with absolute ethanol (1ml/200g p.o.) 2h after ethanol administration, the animals were euthantised, stomachs were excised out. The stomachs excised out from both the study groups were evaluated for ulcer index and percentage protection. However, for multiple dose study group histopathological study was also performed to evaluate cytoprotection.
Result: The results were interpreted statistically using one way ANOVA. The combination group (rabeprazole + vitamin C and rabeprazole + Melatonin) showed significant antiulcer activity in both single and multiple dose study groups, on comparison with rabeprazole, vitamin C and melatonin individually.
Conclusion: The effect of combination groups was found to be synergistic in nature and more effective in treating peptic ulcer disease.
Keywords
Antiulcer activity, Rabeprazole, Vitamin C, Melatonin, Antioxidants, Ethanol induced ulcers
References
- Goodman and Gilman. The pharmacological basis of therapeutics. 10th Edition. New York, McGraw Hill: 2001: 1007.
- http://www.wikipedia.org/wiki/pepticulcers.htm
- Ronald Fernandes. Ph.D. Dissertation work submitted to the Mangalore University. Gastroprotective and antisecretory effect of selenomethionine in albino rats 2008: 1.
- http://www.umm.edu/digest/ulcers.htm.
- Parmar NS, Jagruti K Desai. A review of the current methodology for the evaluation of gastric & duodenal anti-ulcer agents. Indian J Pharmacol 1993; 25: 120-35.
- Morris GP and Wallece JL: The role of ethanol inf acid production of gastric mucosal erosions in rats. Virchows Arch 46:1981; 239-51.
- Qui BS, Cho CH and Ogle CW: Chronic nicotine treatment intensifies gastric ulceration by cold restraint stress in rats. Agents Actions 33: 1991; 367-70.
- Smura H and Marumo F: Effect of acetaminophen on stress induced gastric mucosal lesion in rats. Res Comm. Mol Path Pharmacol 86(3):1994; 297-310.
- Sharma HL and Sharma KK. Principles of Pharmacology. 1st Edition, Paras publications, 2007: 368.
- Bandyopadhyay D, Chattopadhyay A. Reactive oxygen speciesinduced gastric ulceration, protection by melatonin. Curr. Med chem. 2006; 13(10): 1187-1202.
- Manjeet singh, Neelam jaiswal. Oxygen derived free radicals and circulatory shock. Ind J Pharmacol. 1992; 24: 8-11
- Venkatesham A, Sharath babu P, Vidyasagar J, Krishna DR. Effect of reactive oxygen species on cholinergic receptor function. Ind J Pharmacol. 2005; 37(6): 366-70.
- Langseth, L. 1993. Oxidants, antioxidants and disease prevention. International Life Sciences Institute, 1-26.
- Dr Dhrubo Jyoti Sen. Herbal Antioxidants: A Great Hope for future. Pharma Times. 2008; 40(12): 22-36.
- http://www.merckmanuals.com
- 48. Reiter RJ, Tan DX, Sainz RM, Mayo JC, Lopez Burillo S. Melatonin reducing the toxicity and increasing the efficacy of drugs. Journal of Pharmacy and Pharmacology. 2002; 54(10): 1299-1321.
- www.janssen-ortho.com
- Goodman and Gilman. The pharmacological basis of therapeutics. 10th Edition. New York, McGraw Hill: 2001: 1007.
- Avila JR, Lastra CA, Martin MJ. Motilava V, Lauque I, Delgado D, Esteban J and Herrevcas J; role of endogenous sulphahydryl and neutrophil infiltration in pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflam Res. 45:1996; 83-8.
- Ronald Fernandes. Ph.D. Dissertation work submitted to the Mangalore University. Gastroprotective and antisecretory effect of selenomethionine in albino rats 2008: 45.
- Kulkarni SK. Hand book of experimental pharmacology 3rd edition, Vallabh Prakashan, New Delhi. 2005:148-50.
- Fathihah B, Mahmood AA, Sidik K and Salmah I. The antiulcer and cytoprotective effect of ageratum conyzoides–honey combination in rats, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, JUMMEC 2003-2005; 8: 28-32.
- Deshpande SS, Shah GB, Parmar NS. Antiulcer activity of Tephrosia purpurea in rat. Ind.J of pharmacology. 2003; Vol 35: 168-72.
- Pharmacodynamic Influence of Vitamin C and Esomeprazole on Gastro Protection in Pylorus Ligation and Aspirin Induced Ulcers in Rats
Abstract Views :284 |
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Authors
Affiliations
1 Department of Pharmacology, H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka, IN
2 H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka., IN
1 Department of Pharmacology, H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka, IN
2 H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 176-180Abstract
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. The present study was aimed to find out the pharmacodynamic influence of Vitamin C and Esomeprazole and their combination on Gastro intestinal parameters in pylorus ligation and aspirin induced ulcers in rats. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for aspirin induced ulcer model. The antiulcer effect of the combination of vitamin C 4.5 mg/200 g and esomeprazole 0.54 mg/200 g b.w orally was compared with the reference standard esomeprazole 0.54 mg/200 g b.w orally. The ulcer index was calculated and other biochemical parameters of gastric juice were estimated. The ulcer index of combination showed significant (P < 0.05) reduction while other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice showed highly significant (P < 0.001) reduction when compared to control and standard esomeprazole. The percentage protection of combination was 85% as compared to standard esomeprazole 80% in pylorus ligation model. In the aspirin induced model the percentage protection of combination was 90% as compared to standard esomeprazole 85%. Thus the combination group was found to be synergistic in nature when compared to esomeprazole alone in both the models.Keywords
Antiulcer Activity, Vitamin C, Esomeprazole, Pylorus Ligation, NSAIDs, Ulcer Index.References
- Hoogerwerf WA and Pasricha PJ (2001). Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophal reflux disease In: Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th Ed. Maxwell Mac Millan International Eds. Pergamon Press, Inc. Maxwell House, Fairview Park, Elmsford, New York 10523, USA, 1005- 1020.
- Ganong WF (1989). Regulation of Gastrointestinal Function in: Review of Medical Physiology. 14th Ed. Prentice-Hall Englewood Cliffs, New Jersey, USA, 448-466.
- Guyton AC (1991). General Principles of Gastrointestinal Function in: Textbook of Medical Physiology.8thEd.W.B.SaundersCompany,Harcourt Brace Jovanovich, Inc. Philadelphia, PA 19106 USA, 688-697.
- Walter and Isreal (1996). General Pathology, 7th Ed. Churchill Livingstone Inc., 650 Avenues, New York, NY 10011, USA 128, 133-134.
- Shemerovskii KA and Nikul'shina SA (1998). Myoelectric activity of the rabbit stomach and duodenum following neurogenic and humoral effects. Ross Fiziol Zh Im I M Sechenova (Russian); 84(9): 931-939.
- Dr Dhrubo Jyoti Sen. Herbal Antioxidants: A Great Hope for future. Pharma Times. 2008;40(12): 22-36.
- Jan C Becker, Nina Grosser, Peter Boknik, Henning Schroder, Wolfram Domschke, Thorsten Pohle. Gastro Protection by Vitamin C-a heme oxygenase-1-dependent mechanism. Biochemical and Biophysical Research Communications. 2003; 312(2): 507-12.
- Pommerien W, Schultze V, Braden B, Lembcke B, Wrangstadh M, Londong W. Dose-response of Omeprazole combined with amoxycillin on duodenal ulcer healing and eradication of Helicobacter pylori. Aliment Pharmacol Ther 1996; 10: 303-8.
- Laurence DR, Bacharach AL. Evaluation of drug activities and pharmacometrics. London and New York. Academic press; 1:160-61.
- Shay M, Komarov SA, Fels D, Meranze D, Gruenstein H and Siplet. A simple method for uniform production of gastric ulceration in rat. Gastroenterology 1945; 5:43-61.
- Raju. D., Ilango. K., Chitra. V., Ashish. K. Evaluation of Antiulcer activity of methanolic extract of Terminalia Chebula fruits in experimental rats. Journal of Pharmaceutical Sciences and research 2009;1(3):101-107.
- R. K. Goel, S. Gupta, R. Shankar, and A. K. Sanyal, J Ethnopharmacol. 18, 1986.33.
- Patil S.S., Bhide A.A. and Gorle A.M. Antiulcer activity and Ant inflammatory Studies on acacia catechu. Indian Drugs 2010; 47(2):52-53.
- S.K. Kulkarni. Hand book of experimental Pharmacology, Vallabh Prakashan New Delhi, 2002 pp. 149-150.
- H.Gerhard Vogel. Drug Discovery and Evaluation, Springer- Verlag Berlin Heidelberg, New Your 2002 pp. 868.
- Grover JK, Vats V. Proton pump inhibitors. Trop Gastroenterol 1999;20:16-28.
- Rainsford KD. The effect of 5-lipoxygenase inhibitors and leukotrien antagonists on the development of gastric lesion by non steroidal anti-inflammatory drugs in mice.Agents Actions 1987; 21:316-9.
- Goel RK and Bhattacharya SJL. Gastroduodenal mucosal defense and mucosal protective agents. Indian J Exp Bio 1991; 29:701-14.
- Mahendran P, Sabitha KE, Shyamaldevi CV. Prevention of HClethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. J Expl Biol 2002:58-62.
- Evaluation of Gastroprotective Effect of Aqueous Leaf Extract of Commicarpus Chinensis in Pylorus Ligted Albino Rats
Abstract Views :232 |
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Authors
M. A. Halkai
1,
Nitin Mahurkar
2,
M. D. Akhil Ahmed
3,
A. K. Beknal
1,
S. M. Sayeed Ul Hasan
2,
M. Swathi
1
Affiliations
1 Department of Pharmacognosy, H.K.E.'s MTR IPS, Gulbarga - 585 105, IN
2 Department of Pharmacology, H.K.E.'s MTR IPS, Gulbarga - 585 105, IN
3 Department of Pharmacognosy, H.K.E.'s MTR IPS, Sedam Road, Gulbarga - 585 105, IN
1 Department of Pharmacognosy, H.K.E.'s MTR IPS, Gulbarga - 585 105, IN
2 Department of Pharmacology, H.K.E.'s MTR IPS, Gulbarga - 585 105, IN
3 Department of Pharmacognosy, H.K.E.'s MTR IPS, Sedam Road, Gulbarga - 585 105, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 5 (2012), Pagination: 307-310Abstract
Objective
To evaluate the gastroprotective effect of aqueous extract of leaves of Commicarpus chinensis in pylorus ligated albino rats.
Materials and Methods
The plants were collected from the campus Gulbarga University, Gulbarga, Karnataka and authenticated by department of Botany, Gulbarga University, Gulbarga. The leaves were shade dried and subjected to extraction by percolation to obtain aqueous extract. The aqueous extract was evaluated for antiulcer activity by pylorus ligation model in albino rats. Albino rats of either sex weighing between 180-220 g were procured from the Central animal house, MR medical college, Gulbarga, Karnataka. The animals were divided into three groups of six animals in each. The animals were fasted for 48h and subjected to pylorus ligation technique for evaluating the antiulcer effect of C. chinensis. Prior approval of the IAEC was obtained for conduction of experiment.
Results
The aqueous leaf extract showed significant antiulcer activity on comparison with that of standard rabeprazole. The aqueous extract reduced the acidity of gastric juice and increased the pH of the gastric secretions, exhibiting statistically significant ulcer protection activity.
Conclusion
The antiulcer effect of C. chinensis may be due to antioxidant property contributed by the presence of tannins, flavonoids, saponins. Thus, C. chinensis possesses effective antiulcer property.
.Keywords
Commicarpus Chinesis, Pylorus Ligation, Rabeprazole, Antiulcer Activity.References
- Nair R, Chanda S. Activity of some medicinal plants against certain Pathogenic bacterial strains. Indian J Pharmacol. 2006; 38(2): 142-4.
- Vanila D, Ghanthikumar S, Manickam VS. Ethnomedicinal uses of plant in the plains area of tirunelveli - district, tamilnadu, india. Ethnobotanical leaflets 12. 2008; 1198-1205.
- Boxi M, Rajesh Y, Kumar RV, Praveen B, Mangamma K. Extraction, phytochemical screening and in vitro evaluation of antioxidant properties of Commicarpus chinensis (aqueous leaf extract). Int J Pharma Bio Sci 2010; 1(4): 537- 47.
- Harvey S.K. A preliminary experimental study of the diuretic activity of some indigenous drugs. Indian J Med Res. 1966; 54(8): 774-78.
- Mohan VR, Chinnamadasam. Nutritional and antinutritional evaluation of some unconventional wild edible plants. Tropical and Subtropical agroecosystems 2010; 12: 495-506.
- Kulkarni SK. Handbook of Experimental Pharmacology 3rd Ed. Vallabh Prakashan, New Delhi. 2005: 148-50.
- Gastroprotective Influence of Vitamin C and its Combination with Rabeprazole in Pylorus Ligation Induced Ulcers
Abstract Views :260 |
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Authors
Affiliations
1 Department of Pharmacology, HKES College of Pharmacy, Gulbarga–585 105, Karnataka, IN
1 Department of Pharmacology, HKES College of Pharmacy, Gulbarga–585 105, Karnataka, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 4, No 2 (2014), Pagination: 71-76Abstract
Aim: To assess the influence of Vitamin C (antioxidant) and its combination with rabeprazole in the treatment of peptic ulcer in pylorus ligated rats.
Methodology: The study was divided into 2 dose regimen groups - single and multiple doses. Each regimen group consists of Wistar albino rats of either sex (180-220g) that were divided into 4 groups of 6 animals in each. In single dose regimen group, the animals were fasted for 48 h, after which the drugs and their combination were administered. After 1 h of drug administration the pylorus ligation was performed. However, in multiple dose regimens, the drug and their combination were administered for 07 consecutive days. On 7th day following drug administration the animals were fasted for 48 h and pylorus ligation was performed under ether anesthesia. In both dose regimen groups, the following biochemical parameters were evaluated - volume of gastric juice (ml), pH, free acidity (mEq/L), total acidity (mEq/L) and ulcer index. Histopathology was performed on the stomachs treated with multiple dose regimens.
Results: The interpretation of the results was done statistically using one way ANOVA by Dunnett's test. It was found that the group treated with combination of rabeprazole and vitamin C exhibited significant enhancement of antiulcer activity in both regimen groups on comparison with groups treated with rabeprazole and vitamin C individually.
Conclusion: The combination of vitamin C and rabeprazole was found to be synergistic in nature and more effective in treating peptic ulcer disease upon comparison with standard rabeprazole alone.
Keywords
Antiulcer Activity, Rabeprazole, Vitamin C, Antioxidant, Pylorus Ligation.References
- Marshall BJ, Warron JR. Unidentified curved bacilli in stomach of patients with gastritis and peptic ulceration. Lancet. 1984: 1311-15.
- Ronald Fernandez. Ph.D. Dissertation work submitted to the Mangalore University. Gastroprotective and antisecretory effect of selenomethionine in albino rats 2008: 1.
- Dandagi PM, Patil MB, Mastiholimatu VS, Gadad AP, Kulkarni AR. Antiulcer activity of extracts of calotropis gigantean ischolar_main extracts in pylorus ligated rat model. Int. J Pharmacol. Biol. Sci. 2008; 2(1): 127-32.
- Sharma HL and Sharma KK. Principles of Pharmacology. 1st Edition, Paras publications, 2007: 368.
- Goodman and Gilman. The pharmacological basis of therapeutics. 10th Edition. New York, McGraw Hill: 2001: 1005-6.
- Barar FSK. Essentials of Pharmacotherapeutics. 3rd Edition. 2003: 538-9.
- <http://www.umm.edu/digest/ulcers.htm>
- Langseth L. 1993. Oxidants, antioxidants and disease prevention. International Life Sciences institute, 1-26.
- Dr Dhrubo Jyoti Sen. Herbal Antioxidants: A Great Hope for future. Pharma Times. 2008; 40(12): 22-36.
- http://www.merckmanuals.com
- www.janssen-ortho.com
- Goodman and Gilman. The pharmacological basis of therapeutics. 10th Edition. New York, McGraw Hill: 2001: 1007.
- Shay M, Kemerovo SA, Fels D, Meranze D, Gruenstein H and Siplet: A simple method for uniform production of gastric ulceration in rat. Gastroenterology 5: (1945); 43-61.
- Kulkarni SK. Hand book of experimental pharmacology 3rd edition, Vallabh Prakashan, New Delhi. 2005:148-50.
- Fathihah B, Mahmood AA, Sidik K and Salmah I. The antiulcer and cytoprotective effect of ageratum conyzoides–honey combination in rats, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, JUMMEC 2003-2005; 8: 28-32.
- Deshpande SS, Shah GB, Parmar NS. Antiulcer activity of Tephrosia purpurea in rat. Ind. J of pharmacology. 2003; 35:168-72.
- Evaluation of Wound Healing Effect of Polyherbal Ointment in Alloxan Induced Diabetic Rats
Abstract Views :174 |
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Authors
Affiliations
1 Department of Pharmacology, Sai Pranavi College of Pharmacy, Keesara, RR Dist., Hyderabad, Andhra Pradesh, IN
2 Department of Pharmacology, HKES College of Pharmacy, Gulbarga, Karnataka, IN
1 Department of Pharmacology, Sai Pranavi College of Pharmacy, Keesara, RR Dist., Hyderabad, Andhra Pradesh, IN
2 Department of Pharmacology, HKES College of Pharmacy, Gulbarga, Karnataka, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 6, No 1 (2015), Pagination: 38-43Abstract
To design a polyherbal ointment and assess its wound healing property in alloxan induced diabetic rats. Based on the literature survey, 04 plants with proven wound healing property were selected; the parts of the plants were collected and subjected to extractions using ethanol as solvent. The herbal extracts obtained were incorporated in a simple ointment base by fusion method. Wistar albino rats weighing between 180-200g of either sex were used for screening the polyherbal ointment. Diabetes was induced chemically using alloxan (150mg/kg; i.p.) and the wound healing property was assessed by excision wound model. The results were statistically interpreted by one way ANOVA followed by Dunnett's test and were compared with that of standard ointment formulation framycetin. From the results, it is clearly evident that the polyherbal ointment posses significant wound healing effect in diabetic rats. Thus, it is concluded that the designed Polyherbal ointment is an effective wound healing formulation.Keywords
Polyherbal Ointment, Wound Healing Activity, Alloxan Induced Diabetes.- Synergistic Antiulcer Effect of Melatonin and Esomeprazole Combination in Pylorus Ligation, Ethanol, Aspirin Induced Peptic Ulcers
Abstract Views :174 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, HKES College of Pharmacy, Gulbarga – 585 105, Karnataka, IN
2 Department of Pharmacology, Sai Pranavi College of Pharmacy, Keesara, Hyderabad – 501 504, Andhra Pradesh, IN
1 Department of Pharmacology, HKES College of Pharmacy, Gulbarga – 585 105, Karnataka, IN
2 Department of Pharmacology, Sai Pranavi College of Pharmacy, Keesara, Hyderabad – 501 504, Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 1 (2015), Pagination: 10-14Abstract
The aim of the present study is to assess the synergistic effect of melatonin and esomeprazole combination in the treatment of peptic ulcers using Pylorus ligation, Ethanol and Aspirin ulcer inducing models. Wistar albino rats of either sex weighing between 180-200 gms were used in the study. For each ulcer model, the animals were randomly divided into 04 groups of 06 animals in each. Following acclimatization, the animals were subjected to administration of drugs and combination for 07 consecutive days. On the 7th day, after the administration of the drugs, the animals were fasted for 48h. At the end of 48h, the animals were subjected to ulcer induction using pylorus ligation, ethanol (1ml/200gm; p.o.) and aspirin (20mg/kg; p.o.) models. Various biochemical parameters were assessed - in pylorus ligation model, pH, volume of gastric juice (ml), free and total acidity (mEq/L) and ulcer index were assessed and in aspirin and ethanol induced ulcer models, ulcer index and percentage protection were evaluated. The results were interpreted using one way ANOVA followed by Dunnett's test. It was observed that the combination was effective synergistically in treating peptic ulcers, as it significantly enhanced the antiulcer effect upon comparison with the other treatment groups. From the results obtained, it was concluded that the combination is synergistic in nature.Keywords
Antioxidant, Melatonin, Proton Pump Inhibitor, Esomeprazole.- Antihyperlipidemic Effect of Polyherbal Formulation (PHF) in High Fat Diet Induced Hyperlipidemia
Abstract Views :208 |
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Authors
Affiliations
1 Department of Pharmacology, HKES’s College of Pharmacy, Gulbarga, Karnataka, IN
1 Department of Pharmacology, HKES’s College of Pharmacy, Gulbarga, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 1 (2015), Pagination: 11-14Abstract
The present study was undertaken to design and assess the influence of polyherbal formulation (PHF) on lipid profile in hyperlipidemic rats. The chronic hyperlipidemia was induced in wistar albino rats of either sex using high fat diet i.e. mixture of coconut oil and vanaspati ghee (2:3 v/v). The rats were fed with high fat diet for a period of 08 consecutive weeks. After the treatment with PHF, the following biochemical parameters were evaluated - serum total cholesterol, triglycerides, low density lipo-protein cholesterol (LDL), very low density lipo-protein cholesterol (VLDL) and serum high density lipo-protein cholesterol (HDL). The treatment with PHF (100 and 200 mg/kg, p.o.) significantly reduced the hyperlipidemia, by decreasing the levels of total serum cholesterol, LDL, VLDL and by increasing the HDL in a dose dependent manner, when compared to the control vehicle and standard drug Atorvastatin. The results demonstrated that the PHF possess significant antihyperlipidemic activity.Keywords
Hyperlipidemia, High Fat Diet, Polyherbal Formulation.- Antiulcer Activity of Commicarpus chinensis in Ethanol and Aspirin Induced Ulcers
Abstract Views :217 |
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Authors
Affiliations
1 Department of Pharmacology, HKES College of Pharmacy, Gulbarga–585 105, Karnataka, IN
2 Department of Pharmacology, MAK College of Pharmacy, Moinabad–501 504, Andhra Pradesh, IN
1 Department of Pharmacology, HKES College of Pharmacy, Gulbarga–585 105, Karnataka, IN
2 Department of Pharmacology, MAK College of Pharmacy, Moinabad–501 504, Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 4, No 3 (2014), Pagination: 119-122Abstract
Aim: To assess the antiulcer effect of aqueous leaf extract of Commicarpus chinensis in ethanol and aspirin induced ulcerations.
Material and Method: Wistar albino rats of either sex weighing between 180-220g were used for the study. The plants were collected from Gulbarga University campus, Gulbarga, Karnataka and shade dried, subjected to soxhlet extraction using water as solvent to obtain aqueous extract. The extract was evaluated for its antiulcer activity by using ethanol, aspirin induced ulcer models. For each model, the animals were divided into 3 groups of 6 animals in each. The animals were fasted for 48h and subjected to ulcer induction for evaluating the antiulcer effect of C. chinensis. Prior approval of the IAEC was obtained for conducting antiulcer experiment.
Results: The results were interpreted using one way ANOVA, followed by Dunnett's test. The aqueous leaf extract showed significant antiulcer activity on comparison with standard drug rabeprazole. The aqueous extract significantly reduced the ulcer index and enhanced the percentage protection in a dose dependent manner.
Conclusion: The antiulcer effect of C. chinensis may be due to antioxidant property due the presence of tannins, flavonoids, saponins. C. chinensis is an effective antiulcer agent.